Long-Term Effects

Immune system

It seems tha cannabinoids can ater the body's immune defenses ( NK cells ) .The immune system helps the body defend itself against bacteria and other viruses .

Anandamide , an endogenous ligand of cannabinoid receptors , also proves to interact with the immune system : it inhibits cell proliferation and induces cell death by a singular phenomenon , apoptosis .

Furthermore , it was proved that the presence of THC in the immune system would have an immunosuppressive effect : defences of the body are diminished . Indeed THC activates the cells and thus the MDSC , natural body defence , are reduced .

The MDSC are cells tha cause the reduction or elimination of immune reply against the bacteria and some cancer cells .



Cannabis and spermatogenesis

Consumption of cannabis in large numbers would induce a significant decrease of spermatozoa in sperm concentration with decreased mobility and increased number of abnormal sperm .

Cannabinoids act directly on the germinal epithelium during spermatogenesis



Cannabis and embryo

TCH is able to cross the placental barrier.
THC is in direct contact with tissues in early embryo formation and disrupts the normal processes of neural development. Prenatal exposure to THC leads to its fixation by an alteration of the nervous system of the embryo, which may become permanent.

Altered neuronal


It has not been demonstrated that consumption of cannabis had an incurable impact on neurons: it has no neurotoxicity.

However, recent studies showed a modification of the expression of some genes that cause the structure of the neuron, located in the area of the brain called the hippocampus after three weeks (exposure) to THC .

Although this effect is not incurable , too little experiences have been made to state that the THC is not dangerous for the brain .

 

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